Preheat your oven to 375°F.
Boil the pasta in salted water. Cook until it's a little firm (al dente).
Drain the pasta and put it in a large bowl.
Melt butter in a medium saucepan over medium heat.
Add flour and stir for 1-2 minutes.
Slowly add milk while stirring.
Add cream and stir until the sauce thickens a little.
Add cheddar, mozzarella, and Parmesan cheese. Stir until melted.
Add garlic powder, onion powder, salt, and pepper.
Pour the cheese sauce over the pasta and mix well.
Put the pasta and cheese mixture into a greased baking dish.
Mix breadcrumbs with melted butter and sprinkle on top.
Bake for 25 minutes until the top is golden and bubbly.
Let it sit for 5 minutes before serving.